CapSenze Biosensor System

  • Overview

    The CapSenze Biosystem offers:

    • a bioanalytical platform with extremely high sensitivity and quick & reliable results, combined with an analytical stability that makes it unique and commercially competitive.
    • a capacitive biosensor that combines an extremely high sensitivity with an analytical stability that makes it unique and commercially viable.
    • a unique way to detect and quantify extremely low concentrations of substances such as host cell proteins, endotoxins in biotechnological product streams or infectious agents like HIV or hepatitis virus in blood samples.
    • a system that can be used to determine specificity, kinetics and
      affinity, amongst other binding characteristics of biomolecules and
      macrostructures of varying species such as cells, antibodies, proteins,
      viruses and bacteria.

  • Technical details and applications

    Integrated flow injection system

    • Dimensions 24 × 37 × 25 cm
    • Operated using a syringe pump and and a multiport smart valve
    • Controlled by CapSenze software
    • Automatic serial injection of standard samples and unknown

     

    Performance

    • Ultrasensitive (10-13 to 10-20 M range)
    • Real-time monitoring of protein analytes at contaminant level
    • Suitable for process control
    • Applicable to a wide range of different target analytes

  • Learn more

    Bacterial toxins:

    Sub-attomolar detection of cholera toxin using a label-free capacitive immunosensor. Biosensors and Bioelectronics, 2010, 25, 977-983.

    A capacitive biosensor for detection of staphylococcal enterotoxin B. Analytical and Bioanalytical Chemistry, 2009, 393, 1539-1547.

    A capacitive immunosensor for detection of cholera toxin. Analytica Chimica Acta, 2009, 634, 255-261.

    Capacitive biosensor for monitoring of endotoxin in fermentation fluids. Analytical and Bioanalytical Chemistry, 2007, 389, 517-525.

    Biotechnological production:

    Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production. Trends in Biotechnology, 2010 28, 20-27.

    Sampling and Sample Handling for Process Control.  Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell technology, 2010, 1–23.

    A multipurpose capacitive biosensor for assay and quality control of human immunoglobulin G. Biotechnology and Bioengineering, 2009, 104, 312-320.

    Miscellaneous

    Continuous measurements of a binding reaction using  a capacitive biosensor. Biosensors and Bioelectronics, 2005, 21, 41-48.

    Competitive capacitive biosensing technique (CCBT): A novel technique for monitoring low molecular mass analytes using glucose assay as a model study. Analytical and Bioanalytical Chemistry, 2010, 397, 1217-1224.

    A novel competitive capacitive glucose biosensor based on concanavalin A-labeled nano-gold colloids assembled on a polytyramine-modified gold electrode. Analytica Chimica Acta, 2010, 5, 194-200.