A sensitive and real-time assay of trypsin by using molecular imprinting-based capacitive biosensor

Posted 5 years ago


Development of Technical Tools
Periodontitis and peri-implantitis are biofilm-induced inflammatory diseases associated with teeth or dental implants. They affect around 40% of the Swedish population aged over 50 years and in approximately 20% of cases the disease leads to such extensive destruction of the bone supporting the teeth or implants that they are lost. In this synergy project, CapSenze is in collaboration with Malmö University, Oral Biology and Biomedical Sciences. CapSenze’s role in this project is to develop diagnostic tools for rapid detection and characterization of periodontitis and peri-implantitis disease biomarkers. A new generation of robust, mass-producible, sensitive and highly selective molecularly imprinted polymers (MIPs) or “plastic antibodies”, which are produced by a technique called “molecular imprinting” and offer an entirely new platform for protein assays and sensors, are developed to detect key virulence determinants from bacteria or host-derived molecules involved in inflammatory reactions to polymicrobial biofilms. The produced MIPs are used as receptors in CapSenze biosensor devices for real-time detection of biomarkers in saliva or directly in the gingival or periodontal pockets.

About the project
This project is supported by The KK-Foundation for research, project number 20150086.