Capacitive biosensors for ultra-sensitive assays

Posted 3 years ago

Capacitive biosensors for ultra-sensitive assays
Bo Mattiasson a,b,*, Martin Hedström a,b
a CapSenze Biosystems AB, Medicon Village, Lund, Sweden
b Department of Biotechnology, Lund University, Lund, Sweden

ARTICLEINFO
Keywords:
Capacitive transduction, Ultra-sensitive, Affinity biosensor, Gold surface, Electropolymerization, MIP, Microcontact imprinting

ABSTRACT
Capacitive binding assays have long been considered highly sensitive. The underlying method in such
assays includes sending short potential pulses and then registering the current. However, with the introduction
of current pulses and registration of potential responses, the stability improved significantly,
leading to assays of extreme sensitivities. The new assaying technology has been applied in a range of
affinity binding assays, from immunoassays via DNA base pairing to the use of molecularly imprinted
polymers (MIPs). Overall, very good sensitivities have been recorded, and the MIPs exhibit high stability
and reusability.

http://dx.doi.org/10.1016/j.trac.2015.10.016